PRSS37

Across TCGA patient cohorts, PRSS37 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS37-associated genes across cancer lineages are PCNA, ATM, and eIF4E. Each is linked with PRSS37 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS37-to-partner and partner-to-PRSS37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PRSS37-low versus PRSS37-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS37→partner) and Y-score (partner→PRSS37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.309	+3.330	.007	.005	3	2
COAD	ATM →	-0.723	-3.313	<.001	.010	3	2
COAD	eIF4E →	+0.252	+2.820	.002	.035	3	2
UCEC	FoxM1 →	+0.269	+3.459	.038	.005	3	1
UCEC	ACC_pS79 →	+0.378	+2.321	.030	.035	3	1
UCEC	GATA6 →	-0.166	-3.452	.032	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PCNA by PRSS37 expression — COAD

Explore this box plot interactively →