PRSS37

Across TCGA cell cohorts, PRSS37 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRSS37-associated genes across cancer lineages are SIGLEC8, IL9, and OR13C4. Each is linked with PRSS37 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS37-to-partner and partner-to-PRSS37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by PRSS37-low versus PRSS37-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS37→partner) and Y-score (partner→PRSS37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLEC8 →	+0.025	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	IL9 →	+0.037	+5.228	.001	.005	3	1
LUNG_NSCLC_LUAD	OR13C4 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20B →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20A →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20D →	+0.036	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SIGLEC8 by PRSS37 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →