PRSS33

Across TCGA patient cohorts, PRSS33 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS33-associated genes across cancer lineages are RNA5SP458, RNA5SP189, and RN7SL152P. Each is linked with PRSS33 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS33-to-partner and partner-to-PRSS33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP458 grouped by PRSS33-low versus PRSS33-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS33→partner) and Y-score (partner→PRSS33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP458 →	+0.270	+4.594	.001	.008	3	2
BRCA	RNA5SP189 →	+0.559	+7.731	<.001	.009	3	2
UCEC	RN7SL152P →	+0.318	+2.812	<.001	.008	3	2
BRCA	DUX4L28 →	+0.074	+9.057	<.001	.003	3	1
SKCM	RNU7-115P →	+0.684	+4.188	<.001	.009	3	1
SKCM	RN7SL708P →	+0.171	+5.328	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

RNA5SP458 by PRSS33 expression — SKCM

Explore this box plot interactively →