PRSS33

Across TCGA pan-cancer cohorts, PRSS33 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PRSS33 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PRSS33 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRSS33 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

BRCA, HNSC, and LGG are the cancer types where PRSS33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.359	0.622	<.001	86	view →
HNSC	DFS	Median	All	0.784	0.656	.002	79	view →
LGG	OS	Median	All	0.319	0.589	<.001	51	view →
UCEC	OS	Quartile	All	0.924	0.827	.015	22	view →
SCLC	OS	Tertile	IV	0.164	0.599	.001	18	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	18	view →
KIRP	OS	Median	IV	0.043	0.523	.020	12	view →
KICH	DFS	Tertile	III,IV	0.043	0.897	.045	9	view →
SKCM	OS	Median	All	0.488	0.304	.011	9	view →
OV	OS	Quartile	IV	0.202	0.441	.031	8	view →
UCS	DFS	Median	II,III,IV	0.162	0.528	.010	6	view →
PAAD	DFS	Median	III,IV	0.893	0.470	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PRSS33–BRCA (DFS)

Open the BRCA breakdown →