Q-omics provides the consensus-scored DUX4L28 profile across patient tissues and cancer cell-line models. DUX4L28 expression is associated with patient survival in 4 of 34 cancer types, with the highest sampling consensus in LAML. Additionally, DUX4L28 RNA expression shows 2,612 significant gene co-expression associations, with the highest sampling consensus in LUSC. Together, these results highlight LAML, and LUSC as cancer lineages where DUX4L28 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes DUX4L28 survival associations across molecular data types. DUX4L28 RNA expression shows survival associations in the most cancer types (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DUX4L28 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	4	LAML (36)	view →

This table ranks reproducible DUX4L28 RNA expression–survival associations across cancer types. High DUX4L28 expression shows unfavorable associations in LAML, CESC, KIRP and BRCA. The LAML Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .010). Together, the overview and detailed table identify LAML as the clearest survival context for DUX4L28 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LAML	DFS	Tertile	All	0.111	0.572	.010	36	view →
CESC	DFS	Tertile	All	0.193	0.740	.010	36	view →
KIRP	OS	Tertile	All	0.270	0.904	<.001	27	view →
BRCA	OS	Tertile	All	0.211	0.580	.008	24	view →

Pink = unfavorable, green = favorable. all 4 lineages →

DUX4L28-LAML (DFS)

Kaplan–Meier survival curve for DUX4L28 RNA expression in LAML: high vs low expression groups.

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Cross-omics associations

This table shows molecular features associated with DUX4L28 in patient tissues and cancer cell lines. In patient samples, DUX4L28 shows the broadest associations at the RNA and protein expression levels, with LUSC recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	2,612	LUSC (2349)	view →
Mutation	110	LUSC (75)	view →