PRSS16

Across TCGA patient cohorts, PRSS16 mutation is significantly associated with the RNA expression of many other genes, with 3,264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS16-associated genes across cancer lineages are ENTR1, RPUSD2, and CIAPIN1. Each is linked with PRSS16 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS16-to-partner and partner-to-PRSS16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENTR1 grouped by PRSS16-low versus PRSS16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS16→partner) and Y-score (partner→PRSS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENTR1 →	+0.481	+3.828	<.001	<.001	3	3
UCEC	RPUSD2 →	+0.343	+2.403	.002	<.001	3	3
UCEC	CIAPIN1 →	+0.442	+2.413	.001	<.001	3	3
UCEC	FOXM1 →	+0.829	+3.849	.001	<.001	3	3
GBM	RN7SL435P →	+0.239	+5.352	<.001	.005	3	2
LIHC	MIR604 →	+0.421	+4.567	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,264 associations by consensus.

ENTR1 by PRSS16 expression — UCEC

Explore this box plot interactively →