PRRC2B

Across TCGA patient cohorts, PRRC2B mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRC2B-associated genes across cancer lineages are GAPDH, Stathmin, and Di-Ras3. Each is linked with PRRC2B in more than 4 cancer types. Because this analysis shows association rather than direction, both PRRC2B-to-partner and partner-to-PRRC2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PRRC2B-low versus PRRC2B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC2B→partner) and Y-score (partner→PRRC2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.591	+3.169	.002	.017	3	5
SKCM	Stathmin →	+0.133	+1.700	.028	.038	3	5
LUAD	Di-Ras3 →	-0.108	-3.169	.036	.019	3	3
COAD	eIF4E →	+0.247	+2.472	<.001	.010	3	3
COAD	PCNA →	+0.291	+2.123	.002	.010	3	3
COAD	TIGAR →	+0.318	+1.593	.041	.043	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

GAPDH by PRRC2B expression — COAD

Explore this box plot interactively →