PRRC2B

Across TCGA pan-cancer cohorts, PRRC2B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PRRC2B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PRRC2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRRC2B is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where PRRC2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRRC2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.126	<.001	11	view →
COAD	All	II,III,IV	+0.539	<.001	9	view →
LIHC	Female	II,III,IV	+1.309	<.001	7	view →
THCA	All	All	−0.541	.002	7	view →
CHOL	All	All	+2.323	<.001	5	view →
STAD	All	II,III,IV	+0.943	.001	5	view →
LUSC	All	All	+0.617	<.001	5	view →
KIRC	Male	II,III,IV	−0.511	.004	4	view →
BLCA	All	IV	−0.929	.019	2	view →
READ	All	III,IV	+0.805	.009	2	view →
UCEC	All	All	−0.695	.019	2	view →
BRCA	Female	All	−0.219	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PRRC2B–HNSC

Open the HNSC breakdown →