PRRC2B

Across TCGA pan-cancer cohorts, PRRC2B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PRRC2B data layer compared with 13 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRRC2B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PRRC2B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, ACC, and UCS are the cancer types where PRRC2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.711	0.552	<.001	88	view →
ACC	DFS	Median	All	0.360	0.784	<.001	83	view →
UCS	DFS	Median	IV	0.952	0.367	.001	54	view →
BLCA	DFS	Tertile	All	0.270	0.438	.005	47	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	32	view →
HNSC	DFS	Median	All	0.746	0.643	.005	30	view →
CESC	DFS	Tertile	III,IV	0.520	0.909	.009	24	view →
THCA	OS	Tertile	II,III,IV	0.714	1.000	.010	23	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	16	view →
LIHC	DFS	Tertile	All	0.493	0.617	.008	14	view →
GBM	DFS	Quartile	All	0.346	0.218	.030	9	view →
PAAD	OS	Tertile	All	0.716	0.452	.003	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PRRC2B–KIRC (DFS)

Open the KIRC breakdown →