PRRC2B

Across TCGA cell cohorts, PRRC2B mutation is significantly associated with the RNA expression of many other genes, with 1,092 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRC2B-associated genes across cancer lineages are PDE10A, EPS8L1, and ZCRB1. Each is linked with PRRC2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRC2B-to-partner and partner-to-PRRC2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE10A grouped by PRRC2B-low versus PRRC2B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC2B→partner) and Y-score (partner→PRRC2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PDE10A →	+1.061	+2.643	<.001	.002	3	2
LARGE_INTESTINE	EPS8L1 →	-1.474	-3.044	<.001	<.001	3	2
BLOOD_Leukemia	ZCRB1 →	+0.403	+2.552	.004	.004	3	2
BLOOD_Leukemia	NEDD1 →	+0.632	+2.380	.004	.008	3	2
BLOOD_Leukemia	CPXCR1 →	+0.041	+2.038	.002	.002	3	2
BLOOD_Leukemia	GSN →	-2.051	-2.777	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,092 associations by consensus.

PDE10A by PRRC2B expression — BLOOD_Leukemia

Explore this box plot interactively →