PRR5L

Across TCGA patient cohorts, PRR5L mutation is significantly associated with the RNA expression of many other genes, with 835 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR5L-associated genes across cancer lineages are MIR6766, RN7SL248P, and RPS29P32. Each is linked with PRR5L in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR5L-to-partner and partner-to-PRR5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6766 grouped by PRR5L-low versus PRR5L-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR5L→partner) and Y-score (partner→PRR5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6766 →	+0.466	+4.575	<.001	.009	3	2
UCEC	RN7SL248P →	+0.077	+3.606	<.001	.002	3	2
UCEC	RPS29P32 →	+0.370	+2.462	.001	.004	3	2
CESC	KRTAP24-1 →	+0.017	+5.579	<.001	.001	3	2
CESC	PHBP4 →	+0.121	+4.069	<.001	.005	3	2
CESC	SSU72P8 →	+0.714	+4.559	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 835 associations by consensus.

MIR6766 by PRR5L expression — BRCA

Explore this box plot interactively →