Q-omics provides the consensus-scored PHBP4 profile across patient tissues and cancer cell-line models. PHBP4 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, PHBP4 is differentially expressed in 4, with the highest sampling consensus in HNSC. Additionally, PHBP4 RNA expression shows 10,190 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LGG, HNSC, and THYM as cancer lineages where PHBP4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PHBP4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PHBP4 survival associations across molecular data types. PHBP4 RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PHBP4 RNA expression–survival associations across cancer types. High PHBP4 expression shows unfavorable associations in LUAD, STAD and KIRP, but favorable associations in LGG, UCS and SKCM. The LGG Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for PHBP4 RNA expression.
This table summarizes PHBP4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for PHBP4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PHBP4 shows higher tumor expression in HNSC, BRCA, KIRP and COAD. The HNSC box plot shows higher PHBP4 RNA expression in tumor versus normal tissue (log2 FC = +0.130, t-test p < 0.001).
This table shows molecular features associated with PHBP4 in patient tissues and cancer cell lines. In patient samples, PHBP4 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
