PRR5-ARHGAP8

Across TCGA patient cohorts, PRR5-ARHGAP8 mutation is significantly associated with the RNA expression of many other genes, with 3,032 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR5-ARHGAP8-associated genes across cancer lineages are USP14, EMC8, and CCNB1. Each is linked with PRR5-ARHGAP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRR5-ARHGAP8-to-partner and partner-to-PRR5-ARHGAP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP14 grouped by PRR5-ARHGAP8-low versus PRR5-ARHGAP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR5-ARHGAP8→partner) and Y-score (partner→PRR5-ARHGAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	USP14 →	+0.480	+3.721	.001	<.001	3	3
UCEC	EMC8 →	+0.505	+3.566	<.001	<.001	3	3
UCEC	CCNB1 →	+0.675	+2.874	.001	<.001	3	3
UCEC	H2AZ1 →	+0.599	+2.424	<.001	<.001	3	3
UCEC	TRAPPC2L →	+0.328	+2.551	.008	<.001	3	3
UCEC	CDK1 →	+0.614	+2.021	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,032 associations by consensus.

USP14 by PRR5-ARHGAP8 expression — UCEC

Explore this box plot interactively →