PRR5-ARHGAP8

Across TCGA pan-cancer cohorts, PRR5-ARHGAP8 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PRR5-ARHGAP8 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRR5-ARHGAP8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PRR5-ARHGAP8 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LIHC show a favorable association.

KIRC, ACC, and LIHC are the cancer types where PRR5-ARHGAP8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.715	0.555	<.001	67	view →
ACC	DFS	Tertile	II,III,IV	0.097	0.575	<.001	56	view →
LIHC	DFS	Tertile	III,IV	0.496	0.273	.004	48	view →
PAAD	OS	Quartile	All	0.154	0.559	<.001	26	view →
CESC	DFS	Median	All	0.659	0.825	<.001	26	view →
KICH	OS	Median	All	0.741	0.970	.005	22	view →
DLBC	OS	Tertile	All	0.755	0.981	.005	22	view →
PRAD	DFS	Tertile	All	0.668	0.912	<.001	18	view →
READ	OS	Median	IV	0.995	0.538	.008	15	view →
SCLC	DFS	Tertile	IV	0.776	0.169	.010	12	view →
THCA	OS	Tertile	IV	0.583	1.000	.020	11	view →
HNSC	DFS	Quartile	II,III,IV	0.248	0.469	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PRR5-ARHGAP8–KIRC (OS)

Open the KIRC breakdown →