PRR5-ARHGAP8

Across TCGA pan-cancer cohorts, PRR5-ARHGAP8 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PRR5-ARHGAP8’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where PRR5-ARHGAP8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRR5-ARHGAP8 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

STAD, BLCA, and KIRC are the cancer types where PRR5-ARHGAP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRR5-ARHGAP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.480	<.001	11	view →
BLCA	Male	All	+0.213	<.001	11	view →
KIRC	Male	II,III,IV	−0.185	<.001	11	view →
COAD	Male	II,III,IV	+0.454	<.001	10	view →
HNSC	Male	IV	+0.310	<.001	10	view →
BRCA	All	III,IV	+0.415	<.001	6	view →
LUSC	Male	All	+0.414	<.001	5	view →
LUAD	Female	All	+0.249	<.001	5	view →
CHOL	All	All	+0.638	.001	2	view →
ESCA	Female	All	+0.440	.033	2	view →
READ	All	All	+0.432	.002	2	view →
KIRP	All	All	−0.229	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PRR5-ARHGAP8–STAD

Open the STAD breakdown →