PRR5-ARHGAP8

Across TCGA patient cohorts, PRR5-ARHGAP8 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR5-ARHGAP8-associated genes across cancer lineages are PCNA, Cyclin-B1, and Rictor_pT1135. Each is linked with PRR5-ARHGAP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR5-ARHGAP8-to-partner and partner-to-PRR5-ARHGAP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PRR5-ARHGAP8-low versus PRR5-ARHGAP8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR5-ARHGAP8→partner) and Y-score (partner→PRR5-ARHGAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.220	+2.584	.013	.011	3	2
UCEC	Cyclin-B1 →	+0.569	+2.584	.008	.010	3	2
UCEC	Rictor_pT1135 →	-0.097	-1.678	.013	.023	3	2
UCEC	cIAP →	+0.118	+1.348	.025	.045	3	2
UCEC	eIF4E →	+0.267	+2.584	<.001	.001	3	1
UCEC	eIF4G →	+0.341	+3.584	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PCNA by PRR5-ARHGAP8 expression — SKCM

Explore this box plot interactively →