PRPSAP2

Across TCGA patient cohorts, PRPSAP2 mutation is significantly associated with the RNA expression of many other genes, with 1,006 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPSAP2-associated genes across cancer lineages are SCARNA21B, RNA5SP354, and GPR148. Each is linked with PRPSAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPSAP2-to-partner and partner-to-PRPSAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCARNA21B grouped by PRPSAP2-low versus PRPSAP2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPSAP2→partner) and Y-score (partner→PRPSAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SCARNA21B →	+0.476	+5.039	<.001	.008	3	2
HNSC	RNA5SP354 →	+0.310	+4.480	.001	.005	3	2
BLCA	GPR148 →	+0.032	+5.106	.005	.008	3	1
BLCA	RNA5SP204 →	+0.378	+6.444	<.001	.001	3	1
BLCA	RNU6-1175P →	+0.329	+5.497	.003	.004	3	1
UCEC	VWA1 →	-1.365	-4.311	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,006 associations by consensus.

SCARNA21B by PRPSAP2 expression — READ

Explore this box plot interactively →