PRPSAP2

Across TCGA pan-cancer cohorts, PRPSAP2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PRPSAP2 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PRPSAP2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PRPSAP2 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

UCS, ACC, and KIRC are the cancer types where PRPSAP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	II,III,IV	0.706	0.236	.001	68	view →
ACC	DFS	Median	All	0.217	0.670	<.001	62	view →
KIRC	OS	Median	All	0.723	0.541	<.001	57	view →
PAAD	OS	Median	All	0.494	0.278	.001	53	view →
BRCA	DFS	Tertile	III,IV	0.602	0.328	.001	38	view →
LGG	DFS	Median	All	0.501	0.283	<.001	37	view →
LIHC	OS	Median	All	0.701	0.853	<.001	24	view →
LUSC	OS	Tertile	All	0.779	0.674	.011	14	view →
LUAD	DFS	Tertile	III,IV	0.446	0.743	.006	10	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	9	view →
HNSC	OS	Median	All	0.504	0.694	.007	8	view →
OV	OS	Tertile	IV	0.576	0.310	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PRPSAP2–UCS (OS)

Open the UCS breakdown →