PRPSAP1

Across TCGA patient cohorts, PRPSAP1 mutation is significantly associated with the RNA expression of many other genes, with 397 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPSAP1-associated genes across cancer lineages are RNY4P14, RPS3AP17, and SLC25A20P1. Each is linked with PRPSAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPSAP1-to-partner and partner-to-PRPSAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P14 grouped by PRPSAP1-low versus PRPSAP1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPSAP1→partner) and Y-score (partner→PRPSAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNY4P14 →	+0.586	+6.144	<.001	.001	3	2
UCEC	RPS3AP17 →	+0.080	+2.829	.003	.001	3	2
CESC	SLC25A20P1 →	+0.083	+5.539	<.001	.004	3	1
CESC	PDCL2P1 →	+0.208	+6.837	<.001	<.001	3	1
SKCM	COX6CP12 →	+0.084	+3.291	<.001	.006	3	1
SKCM	ZMYND10-AS1 →	+0.114	+2.668	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

RNY4P14 by PRPSAP1 expression — CESC

Explore this box plot interactively →