PRPSAP1

Across TCGA pan-cancer cohorts, PRPSAP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PRPSAP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRPSAP1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRPSAP1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and BLCA are the cancer types where PRPSAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRPSAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.187	<.001	11	view →
KIRC	Male	II,III,IV	−0.650	<.001	10	view →
BLCA	All	All	+0.825	<.001	9	view →
LIHC	Male	All	+1.051	<.001	8	view →
COAD	Female	II,III,IV	+0.438	<.001	8	view →
KICH	Female	II,III,IV	−1.460	<.001	7	view →
LUSC	Male	All	+0.429	<.001	5	view →
STAD	All	II,III,IV	+0.435	.010	4	view →
LUAD	All	IV	+1.105	.013	3	view →
CHOL	All	All	+0.695	.007	2	view →
PRAD	All	All	+0.213	.034	2	view →
BRCA	All	All	−0.158	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PRPSAP1–THCA

Open the THCA breakdown →