PRPH

Across TCGA patient cohorts, PRPH mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible PRPH-associated genes across cancer lineages are RNU7-56P, MIR4285, and MIR521-2. Each is linked with PRPH in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPH-to-partner and partner-to-PRPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-56P grouped by PRPH-low versus PRPH-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPH→partner) and Y-score (partner→PRPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU7-56P →	+0.392	+4.144	<.001	.009	3	2
CESC	MIR4285 →	+0.538	+3.450	<.001	.005	3	2
UCEC	MIR521-2 →	+0.502	+4.484	<.001	.009	3	2
UCEC	PCNPP2 →	+0.102	+5.226	<.001	.003	3	2
UCEC	OR4K17 →	+0.084	+5.335	<.001	.003	3	2
BLCA	SPAM1 →	+0.170	+3.830	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

RNU7-56P by PRPH expression — CESC

Explore this box plot interactively →