PRPH

Across TCGA pan-cancer cohorts, PRPH RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PRPH’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRPH RNA is repressed in tumor relative to normal tissue. In most cancer types PRPH is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and KIRC are the cancer types where PRPH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRPH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−2.035	<.001	11	view →
BLCA	All	IV	−0.507	<.001	11	view →
KIRC	All	All	+0.345	<.001	7	view →
STAD	All	All	−0.791	.003	6	view →
LUAD	Female	All	−0.467	<.001	6	view →
BRCA	Female	All	−0.319	<.001	6	view →
READ	Female	All	−2.574	<.001	5	view →
HNSC	Male	IV	+0.370	.012	4	view →
LUSC	Male	III,IV	−0.615	.004	2	view →
PRAD	All	All	−0.355	<.001	2	view →
CHOL	All	All	+0.182	.045	1	view →
KIRP	Male	All	−0.172	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PRPH–COAD

Open the COAD breakdown →