PRPF19

Across TCGA cell cohorts, PRPF19 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRPF19-associated genes across cancer lineages are G6PC2, OR2C1, and UTS2R. Each is linked with PRPF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF19-to-partner and partner-to-PRPF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PC2 grouped by PRPF19-low versus PRPF19-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF19→partner) and Y-score (partner→PRPF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	G6PC2 →	+0.031	+3.099	<.001	.004	3	1
LARGE_INTESTINE	OR2C1 →	+0.108	+3.578	<.001	.006	3	1
LARGE_INTESTINE	UTS2R →	+0.243	+3.321	<.001	.008	3	1
SKIN	KRTAP15-1 →	+0.050	+6.022	<.001	.001	3	1
BLOOD_Leukemia	FUT5 →	+0.141	+3.681	.009	.005	3	1
BLOOD_Leukemia	GUCY2D →	+0.556	+3.857	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

G6PC2 by PRPF19 expression — LARGE_INTESTINE

Explore this box plot interactively →