PRODH

Across TCGA cell cohorts, PRODH mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRODH-associated genes across cancer lineages are C9orf92, DEFA5, and MT1HL1. Each is linked with PRODH in more than 1 cancer types. Because this analysis shows association rather than direction, both PRODH-to-partner and partner-to-PRODH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by PRODH-low versus PRODH-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRODH→partner) and Y-score (partner→PRODH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
LUNG_NSCLC_LUAD	DEFA5 →	+0.673	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	MT1HL1 →	+0.130	+5.266	<.001	.001	3	1
BLOOD_Lymphoma	OR13C9 →	+0.011	+4.058	.008	.009	3	1
BLOOD_Lymphoma	RNASE3 →	+0.041	+3.523	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C9orf92 by PRODH expression — SOFT_TISSUE

Explore this box plot interactively →