PRODH

Across TCGA pan-cancer cohorts, PRODH RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PRODH data layer compared with 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRODH RNA is associated with better overall survival. In most high-consensus cancer types, elevated PRODH expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

KIRC, ACC, and UCS are the cancer types where PRODH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.714	0.541	<.001	63	view →
ACC	DFS	Median	All	0.785	0.314	<.001	57	view →
UCS	OS	Median	II,III,IV	0.599	0.222	.008	50	view →
CESC	OS	Tertile	II,III,IV	0.858	0.587	.003	38	view →
KIRP	DFS	Median	All	0.906	0.576	.001	35	view →
READ	OS	Median	IV	0.913	0.495	.002	27	view →
LGG	OS	Median	All	0.826	0.946	<.001	26	view →
UVM	DFS	Tertile	All	0.846	0.579	.016	26	view →
SKCM	OS	Median	III,IV	0.253	0.522	.004	23	view →
OV	DFS	Quartile	III,IV	0.426	0.315	.007	22	view →
LUSC	OS	Median	All	0.808	0.629	.007	19	view →
PAAD	DFS	Tertile	All	0.143	0.379	.005	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PRODH–KIRC (OS)

Open the KIRC breakdown →