Across TCGA patient cohorts, PRKG1 mutation is significantly associated with the RNA expression of many other genes, with 4,925 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKG1-associated genes across cancer lineages are PSMD3, FANCA, and KIF11. Each is linked with PRKG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRKG1-to-partner and partner-to-PRKG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKG1→partner) and Y-score (partner→PRKG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PSMD3 →	+0.448	+3.620	.002	.001	3	4
UCEC	FANCA →	+0.736	+2.362	<.001	<.001	3	4
UCEC	KIF11 →	+0.707	+1.960	<.001	<.001	3	4
UCEC	TAF5 →	+0.326	+2.075	.003	<.001	3	4
CESC	PRELID1P2 →	+0.056	+4.516	<.001	.004	3	3
SKCM	RNU6-875P →	+0.240	+1.750	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,925 associations by consensus.

Exploration

PRKG1 survival (RNA) · tumor vs normal (RNA) · all PRKG1 data types