Across TCGA pan-cancer cohorts, PRKG1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PRKG1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRKG1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRKG1 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and LUSC are the cancer types where PRKG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−2.354	<.001	10	view →
BLCA	Male	All	−2.387	<.001	8	view →
LUSC	Female	All	−1.350	<.001	8	view →
LUAD	Female	III,IV	−1.400	<.001	7	view →
KIRP	Female	All	−1.009	<.001	7	view →
UCEC	All	All	−2.996	<.001	6	view →
KICH	Male	IV	−1.373	.005	6	view →
COAD	Female	All	−0.898	<.001	6	view →
STAD	Female	All	−1.321	.013	3	view →
HNSC	Female	III,IV	+1.091	.013	3	view →
READ	All	All	−1.593	<.001	2	view →
PRAD	All	All	−1.119	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

Exploration

Same gene, other analysis: PRKG1 RNA expression & survival · all PRKG1 data types