Across TCGA cell cohorts, PRKG1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRKG1-associated genes across cancer lineages are OR4E2, EXOC1L, and ARSF. Each is linked with PRKG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKG1-to-partner and partner-to-PRKG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKG1→partner) and Y-score (partner→PRKG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR4E2 →	+0.133	+4.906	<.001	.006	3	1
OESOPHAGUS	EXOC1L →	+0.036	+4.906	<.001	.006	3	1
BLOOD_Leukemia	ARSF →	+0.242	+3.705	<.001	.007	3	1
SKIN	TINAG →	+0.233	+3.000	<.001	.006	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
LARGE_INTESTINE	OR1F1 →	+0.349	+2.921	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

PRKG1 survival (RNA) · tumor vs normal (RNA) · all PRKG1 data types