PRKCG

Across TCGA patient cohorts, PRKCG mutation is significantly associated with the RNA expression of many other genes, with 6,899 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCG-associated genes across cancer lineages are FAM72C, RFC2, and RNU6-468P. Each is linked with PRKCG in more than 4 cancer types. Because this analysis shows association rather than direction, both PRKCG-to-partner and partner-to-PRKCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM72C grouped by PRKCG-low versus PRKCG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCG→partner) and Y-score (partner→PRKCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FAM72C →	+0.257	+2.424	<.001	.001	3	5
LUAD	RFC2 →	+0.494	+3.193	.003	.009	3	5
STAD	RNU6-468P →	+0.320	+3.350	<.001	.004	3	4
COAD	CEP76 →	+0.484	+2.834	<.001	.001	3	4
UCEC	DUS4L →	+0.353	+4.021	<.001	<.001	3	4
UCEC	RPA3 →	+0.515	+2.546	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,899 associations by consensus.

FAM72C by PRKCG expression — SKCM

Explore this box plot interactively →