PRKCG

Across TCGA pan-cancer cohorts, PRKCG RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PRKCG’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRKCG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRKCG is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, STAD, and LUAD are the cancer types where PRKCG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKCG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+1.357	<.001	8	view →
STAD	All	II,III,IV	+1.077	<.001	7	view →
LUAD	All	All	+0.214	<.001	7	view →
READ	All	II,III,IV	+2.462	.003	5	view →
HNSC	All	All	+0.102	.003	4	view →
LUSC	All	II,III,IV	+0.187	.019	3	view →
KICH	Male	IV	−0.033	.024	3	view →
KIRP	All	All	+0.225	.008	1	view →
CHOL	Female	All	+0.126	.026	1	view →
BLCA	Male	IV	+0.070	.009	1	view →
LIHC	All	All	+0.025	.026	1	view →
KIRC	All	All	+0.022	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PRKCG–COAD

Open the COAD breakdown →