PRKCG

Across TCGA patient cohorts, PRKCG mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCG-associated genes across cancer lineages are c-Jun_pS73, ASNS, and Caveolin-1. Each is linked with PRKCG in more than 3 cancer types. Because this analysis shows association rather than direction, both PRKCG-to-partner and partner-to-PRKCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Jun_pS73 grouped by PRKCG-low versus PRKCG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCG→partner) and Y-score (partner→PRKCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Jun_pS73 →	-0.115	-2.102	.031	.016	3	4
LUAD	ASNS →	+0.562	+3.169	.021	.019	3	3
LUSC	Caveolin-1 →	-0.829	-3.160	.009	.019	3	3
UCEC	Cyclin-B1 →	+0.716	+3.807	<.001	<.001	3	3
UCEC	eIF4E →	+0.199	+1.874	.004	.002	3	3
UCEC	PCNA →	+0.248	+2.700	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

c-Jun_pS73 by PRKCG expression — UCEC

Explore this box plot interactively →