PRKCG

Across TCGA cell cohorts, PRKCG mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKCG-associated genes across cancer lineages are OR52L1, KLHL40, and PRSS58. Each is linked with PRKCG in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCG-to-partner and partner-to-PRKCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52L1 grouped by PRKCG-low versus PRKCG-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCG→partner) and Y-score (partner→PRKCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR52L1 →	+0.103	+3.947	<.001	.004	3	2
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	2
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUSC	KCNJ6 →	+0.627	+3.321	.009	.006	3	1
LUNG_NSCLC_LUSC	ERICH4 →	+0.153	+3.762	.007	.001	3	1
LUNG_NSCLC_LUSC	NXF2 →	+1.883	+3.836	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

OR52L1 by PRKCG expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →