PRKAG3

Across TCGA cell cohorts, PRKAG3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKAG3-associated genes across cancer lineages are GJA8, DMRTB1, and OR13C8. Each is linked with PRKAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAG3-to-partner and partner-to-PRKAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA8 grouped by PRKAG3-low versus PRKAG3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG3→partner) and Y-score (partner→PRKAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GJA8 →	+0.743	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.007	+5.472	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.027	+4.662	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.040	+5.247	<.001	.001	3	1
BLOOD_Leukemia	ACTRT1 →	+0.028	+5.201	<.001	.006	3	1
BLOOD_Leukemia	AMELX →	+0.038	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GJA8 by PRKAG3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →