PRIMPOL

Across TCGA cell cohorts, PRIMPOL mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRIMPOL-associated genes across cancer lineages are OXT, AVPR1B, and FAM47C. Each is linked with PRIMPOL in more than 1 cancer types. Because this analysis shows association rather than direction, both PRIMPOL-to-partner and partner-to-PRIMPOL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by PRIMPOL-low versus PRIMPOL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRIMPOL→partner) and Y-score (partner→PRIMPOL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	1
SKIN	AVPR1B →	+0.006	+5.415	.007	.004	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OXT by PRIMPOL expression — SKIN

Explore this box plot interactively →