PRIMA1

Across TCGA patient cohorts, PRIMA1 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRIMA1-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD4+ naive T-cells. Each is linked with PRIMA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRIMA1-to-partner and partner-to-PRIMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by PRIMA1-low versus PRIMA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRIMA1→partner) and Y-score (partner→PRIMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD8+ T-cells →	+0.089	+6.142	<.001	.027	3	1
COAD	CD8+ Tcm →	+0.151	+5.917	<.001	.032	3	1
COAD	CD4+ naive T-cells →	+0.047	+6.142	<.001	.027	3	1
UCEC	CMP →	+0.054	+3.180	.001	.010	3	1
UCEC	Basophils →	+0.224	+3.169	.016	.020	3	1
UCEC	Endothelial cells →	-0.046	-3.127	.026	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CD8+ T-cells by PRIMA1 expression — COAD

Explore this box plot interactively →