PRIMA1

Across TCGA pan-cancer cohorts, PRIMA1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PRIMA1 data layer compared with 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PRIMA1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRIMA1 expression acts as an unfavorable survival marker, although some lineages such as MESO and LUSC show a favorable association.

UCEC, UVM, and MESO are the cancer types where PRIMA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.552	0.725	<.001	92	view →
UVM	DFS	Median	All	0.428	0.742	<.001	82	view →
MESO	OS	Tertile	All	0.568	0.278	<.001	76	view →
LGG	OS	Median	All	0.739	0.873	<.001	47	view →
LUSC	DFS	Median	II,III,IV	0.787	0.626	.001	42	view →
CHOL	DFS	Median	All	0.858	0.128	.002	30	view →
THCA	OS	Tertile	All	0.943	1.000	.008	27	view →
ACC	OS	Tertile	III,IV	0.306	0.808	.002	26	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	20	view →
KIRP	DFS	Median	All	0.489	0.675	.012	13	view →
ESCA	OS	Median	All	1.000	0.670	.026	13	view →
KICH	DFS	Quartile	II,III,IV	0.550	0.906	.023	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PRIMA1–UCEC (DFS)

Open the UCEC breakdown →