PRIMA1

Across TCGA pan-cancer cohorts, PRIMA1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PRIMA1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRIMA1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRIMA1 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and KICH are the cancer types where PRIMA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRIMA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−3.286	<.001	12	view →
BLCA	Male	IV	−3.950	<.001	11	view →
KICH	Male	All	−2.328	<.001	11	view →
KIRC	Male	III,IV	+2.240	<.001	11	view →
THCA	All	IV	−1.700	<.001	11	view →
STAD	Female	All	−3.322	<.001	8	view →
LIHC	Male	III,IV	−0.296	<.001	8	view →
READ	Female	All	−3.969	<.001	7	view →
LUAD	Female	III,IV	−1.480	<.001	7	view →
UCEC	All	All	−2.786	<.001	6	view →
BRCA	Female	All	−1.744	<.001	6	view →
LUSC	Male	All	+1.098	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PRIMA1–COAD

Open the COAD breakdown →