PRIMA1

Across TCGA cell cohorts, PRIMA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,714 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRIMA1-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, mRNA splicing, via spliceosome, and Cytoplasmic translation. Each is linked with PRIMA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PRIMA1-to-partner and partner-to-PRIMA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile grouped by PRIMA1-low versus PRIMA1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRIMA1→partner) and Y-score (partner→PRIMA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.081	+0.663	<.001	.001	3	10
OESOPHAGUS	mRNA splicing, via spliceosome →	+0.081	+0.663	<.001	.001	3	10
OESOPHAGUS	Cytoplasmic translation →	+0.103	+0.570	<.001	.007	3	9
OESOPHAGUS	RNA splicing, via transesterification reactions →	+0.082	+0.663	<.001	.001	3	9
OESOPHAGUS	Positive regulation of translation →	+0.094	+0.605	.001	.006	3	9
BONE	Regulation of calcium ion transport →	-0.084	-0.663	.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile by PRIMA1 expression — OESOPHAGUS

Explore this box plot interactively →