PRICKLE3

Across TCGA patient cohorts, PRICKLE3 mutation is significantly associated with the RNA expression of many other genes, with 3,937 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRICKLE3-associated genes across cancer lineages are GLUD1P9, MIR3912, and RN7SL332P. Each is linked with PRICKLE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRICKLE3-to-partner and partner-to-PRICKLE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLUD1P9 grouped by PRICKLE3-low versus PRICKLE3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE3→partner) and Y-score (partner→PRICKLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GLUD1P9 →	+0.024	+7.816	<.001	.008	3	3
UCEC	MIR3912 →	+0.175	+1.690	<.001	.008	3	3
LUSC	RN7SL332P →	+0.294	+4.882	<.001	.005	3	3
LUAD	COPRSP1 →	+0.162	+3.311	<.001	.004	3	3
LUSC	LINC01855 →	+0.320	+4.978	<.001	.005	3	3
CESC	RNU105C →	+0.184	+4.969	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,937 associations by consensus.

GLUD1P9 by PRICKLE3 expression — SKCM

Explore this box plot interactively →