PRICKLE3

Across TCGA pan-cancer cohorts, PRICKLE3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PRICKLE3 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher PRICKLE3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRICKLE3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SCLC show a favorable association.

KICH, KIRP, and LGG are the cancer types where PRICKLE3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	II,III,IV	0.343	0.942	<.001	106	view →
KIRP	DFS	Quartile	All	0.723	0.919	<.001	102	view →
LGG	DFS	Median	All	0.289	0.515	<.001	54	view →
BLCA	OS	Median	IV	0.409	0.149	.005	47	view →
SCLC	OS	Median	All	0.467	0.235	.004	39	view →
LIHC	DFS	Tertile	All	0.323	0.512	<.001	37	view →
LUAD	DFS	Quartile	III,IV	0.360	0.785	.005	37	view →
COAD	DFS	Median	All	0.441	0.590	.003	29	view →
ACC	DFS	Median	III,IV	0.588	0.105	.003	22	view →
ESCA	DFS	Median	All	0.418	0.566	.024	15	view →
SKCM	OS	Quartile	All	0.222	0.384	.003	12	view →
LAML	DFS	Median	All	0.427	0.678	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PRICKLE3–KICH (DFS)

Open the KICH breakdown →