PRICKLE3

Across TCGA cell cohorts, PRICKLE3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRICKLE3-associated genes across cancer lineages are KRTAP12-4, OR7G3, and IQCF5. Each is linked with PRICKLE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRICKLE3-to-partner and partner-to-PRICKLE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP12-4 grouped by PRICKLE3-low versus PRICKLE3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE3→partner) and Y-score (partner→PRICKLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP12-4 →	+0.099	+5.643	<.001	.002	3	1
BLOOD_Leukemia	OR7G3 →	+0.046	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	1
LARGE_INTESTINE	KRT85 →	+0.439	+3.823	<.001	.006	3	1
LARGE_INTESTINE	PROKR1 →	+0.055	+3.725	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

KRTAP12-4 by PRICKLE3 expression — LUNG_SCLC

Explore this box plot interactively →