PRICKLE3

Across TCGA cell cohorts, PRICKLE3 mutation is significantly associated with the mutation status of many other genes, with 2,515 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRICKLE3-associated genes across cancer lineages are STAMBP, HSPG2, and PKN3. Each is linked with PRICKLE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRICKLE3-to-partner and partner-to-PRICKLE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAMBP grouped by PRICKLE3-low versus PRICKLE3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRICKLE3→partner) and Y-score (partner→PRICKLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	STAMBP →	+5.560	+4.736	.003	.003	1	3
BLOOD_Leukemia	HSPG2 →	+1.975	+3.762	.009	.009	1	3
BLOOD_Leukemia	PKN3 →	+3.560	+5.209	<.001	<.001	1	3
BLOOD_Leukemia	RUSC1 →	+3.338	+4.083	.003	.003	1	3
BLOOD_Leukemia	PDE3A →	+4.145	+4.635	.001	.001	1	3
BLOOD_Leukemia	ADCK5 →	+3.560	+4.247	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,515 associations by consensus.

STAMBP by PRICKLE3 expression — BLOOD_Leukemia

Explore this box plot interactively →