PRECSIT

Across TCGA patient cohorts, PRECSIT mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRECSIT-associated genes across cancer lineages are HMX3, MIR378A, and RNU6-79P. Each is linked with PRECSIT in more than 1 cancer types. Because this analysis shows association rather than direction, both PRECSIT-to-partner and partner-to-PRECSIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMX3 grouped by PRECSIT-low versus PRECSIT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRECSIT→partner) and Y-score (partner→PRECSIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMX3 →	+1.540	+4.232	<.001	<.001	3	1
UCEC	MIR378A →	+0.655	+3.370	<.001	.002	3	1
UCEC	RNU6-79P →	+0.381	+3.246	.006	.008	3	1
UCEC	RNA5SP71 →	+0.641	+3.077	.005	.005	3	1
UCEC	RNU4-58P →	+0.285	+3.396	.002	.006	3	1
UCEC	RNU6-1155P →	+0.221	+5.475	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

HMX3 by PRECSIT expression — UCEC

Explore this box plot interactively →