PRECSIT

Across TCGA pan-cancer cohorts, PRECSIT RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PRECSIT data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher PRECSIT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRECSIT expression acts as an unfavorable survival marker, although some lineages such as UCEC and UCS show a favorable association.

UVM, BLCA, and UCEC are the cancer types where PRECSIT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.414	0.778	<.001	120	view →
BLCA	DFS	Median	III,IV	0.358	0.517	.001	78	view →
UCEC	OS	Median	III,IV	0.896	0.757	.002	62	view →
OV	OS	Median	III,IV	0.795	0.874	.006	56	view →
LGG	DFS	Median	All	0.654	0.823	<.001	54	view →
ACC	DFS	Tertile	II,III,IV	0.222	0.684	<.001	52	view →
LIHC	OS	Tertile	All	0.677	0.845	<.001	49	view →
BRCA	OS	Tertile	II,III,IV	0.876	0.952	<.001	47	view →
UCS	DFS	Quartile	II,III,IV	0.482	0.175	.022	46	view →
KIRP	DFS	Quartile	IV	0.043	0.765	.006	46	view →
PAAD	OS	Tertile	All	0.308	0.623	.006	32	view →
STAD	DFS	Tertile	II,III,IV	0.520	0.691	.015	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PRECSIT–UVM (OS)

Open the UVM breakdown →