PRDM8

Across TCGA cell cohorts, PRDM8 mutation is significantly associated with the mutation status of many other genes, with 732 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PRDM8-associated genes across cancer lineages are GBX2, SIX2, and HIC1. Each is linked with PRDM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM8-to-partner and partner-to-PRDM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GBX2 grouped by PRDM8-low versus PRDM8-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM8→partner) and Y-score (partner→PRDM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GBX2 →	+4.614	+4.614	.006	.006	1	3
CNS	SIX2 →	+4.614	+4.614	.006	.006	1	3
CNS	HIC1 →	+5.614	+5.044	.003	.003	1	3
CNS	ZNF609 →	+3.614	+4.954	.001	.001	1	3
CNS	RGS7BP →	+5.614	+5.044	.003	.003	1	3
CNS	MLLT6 →	+4.614	+4.614	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 732 associations by consensus.

GBX2 by PRDM8 expression — CNS

Explore this box plot interactively →