PRDM8

Across TCGA pan-cancer cohorts, PRDM8 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PRDM8 data layer compared with 6 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PRDM8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PRDM8 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

SKCM, KIRP, and UVM are the cancer types where PRDM8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.411	0.268	<.001	112	view →
KIRP	DFS	Tertile	II,III,IV	0.227	0.732	<.001	108	view →
UVM	DFS	Tertile	All	0.289	0.723	<.001	93	view →
MESO	OS	Tertile	All	0.284	0.589	<.001	59	view →
UCS	DFS	Quartile	II,III,IV	0.725	0.163	<.001	42	view →
LUAD	DFS	Quartile	All	0.480	0.743	.002	40	view →
KIRC	OS	Tertile	All	0.542	0.743	.001	31	view →
ACC	OS	Quartile	All	0.210	0.898	.004	26	view →
DLBC	DFS	Median	All	0.643	1.000	.021	18	view →
PCPG	DFS	Tertile	All	0.964	0.797	.006	16	view →
SCLC	DFS	Median	II,III,IV	0.720	0.465	.008	13	view →
LIHC	DFS	Tertile	III,IV	0.559	0.118	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PRDM8–SKCM (OS)

Open the SKCM breakdown →