PRDM6

Across TCGA patient cohorts, PRDM6 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM6-associated genes across cancer lineages are ACVRL1, JNK2, and Ku80. Each is linked with PRDM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM6-to-partner and partner-to-PRDM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by PRDM6-low versus PRDM6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM6→partner) and Y-score (partner→PRDM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.143	-3.439	.016	.005	3	1
UCEC	JNK2 →	+0.367	+3.348	<.001	.004	3	1
UCEC	Ku80 →	+0.257	+3.013	.012	.018	3	1
UCEC	Notch1 →	+0.144	+2.115	.019	.019	3	1
UCEC	p21 →	+0.202	+3.906	.016	<.001	3	1
UCEC	p62 Lck ligand →	+0.345	+2.179	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ACVRL1 by PRDM6 expression — UCEC

Explore this box plot interactively →