PRDM6

Across TCGA cell cohorts, PRDM6 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRDM6-associated genes across cancer lineages are DEFA4, OR5T3, and H1-8. Each is linked with PRDM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM6-to-partner and partner-to-PRDM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by PRDM6-low versus PRDM6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM6→partner) and Y-score (partner→PRDM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
SKIN	OR5T3 →	+0.020	+6.022	<.001	.001	3	1
CNS	H1-8 →	+0.018	+4.772	<.001	.002	3	1
CNS	CFHR2 →	+0.046	+4.772	<.001	.002	3	1
STOMACH	OR52E2 →	+0.084	+4.285	<.001	.007	3	1
STOMACH	OR52E4 →	+0.162	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

DEFA4 by PRDM6 expression — LARGE_INTESTINE

Explore this box plot interactively →