PRDM6

Across TCGA cell cohorts, PRDM6 mutation is significantly associated with the mutation status of many other genes, with 1,882 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRDM6-associated genes across cancer lineages are DLG2, NRXN2, and BCL11B. Each is linked with PRDM6 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRDM6-to-partner and partner-to-PRDM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLG2 grouped by PRDM6-low versus PRDM6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM6→partner) and Y-score (partner→PRDM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DLG2 →	+2.284	+3.925	.005	.005	1	5
LARGE_INTESTINE	NRXN2 →	+2.159	+3.807	.007	.007	1	4
LARGE_INTESTINE	BCL11B →	+2.574	+4.182	.003	.003	1	4
CNS	UBTF →	+5.277	+4.459	.005	.005	1	3
CNS	THBS4 →	+5.277	+4.459	.005	.005	1	3
CNS	DBN1 →	+3.541	+4.139	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,882 associations by consensus.

DLG2 by PRDM6 expression — LARGE_INTESTINE

Explore this box plot interactively →