PRB4

Across TCGA patient cohorts, PRB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,757 significant associations in total. ESCA shows the largest number of these associations.

The most reproducible PRB4-associated GO terms across cancer lineages are RNA 3'-end processing, Regulation of translational initiation, and Transport along microtubule. Each is linked with PRB4 in more than 11 cancer types. Because this analysis shows association rather than direction, both PRB4-to-partner and partner-to-PRB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA 3'-end processing grouped by PRB4-low versus PRB4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB4→partner) and Y-score (partner→PRB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	RNA 3'-end processing →	+0.041	+0.137	.001	<.001	3	11
LAML	Regulation of translational initiation →	+0.048	+0.711	<.001	<.001	3	11
STAD	Transport along microtubule →	+0.037	+0.123	<.001	.003	1	12
LAML	RNA methylation →	+0.034	+0.741	<.001	<.001	3	10
ESCA	Obsolete histone modification →	+0.037	+0.139	.002	<.001	3	10
STAD	Regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.079	+0.218	<.001	<.001	1	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,757 associations by consensus.

RNA 3'-end processing by PRB4 expression — ESCA

Explore this box plot interactively →